|
rs6994992
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, since NRG1 rs6994992 is not a schizophrenia risk variant in the Han Chinese population, the validated association suggested that ethnic difference may exist in the relationship between NRG1 rs6994992, schizophrenia and creativity.
|
31649580 |
2019 |
|
rs10503929
|
|
|
0.030 |
GeneticVariation |
BEFREE |
After adding new reports, the T-allele of NRG1 SNP8NRG241930 (rs62510682) across all studies (OR = 0.95, 95% CI = 0.91-0.997, p = 0.04, N = 22,898) and in Caucasian samples (OR = 0.95, 95% CI = 0.90-0.99, p = 0.03, N = 16,014), and the C-allele of NRG1 rs10503929 across all studies (OR = 0.89, 95% CI = 0.81-0.97, p = 0.01, N = 6844) and in Caucasian samples (OR = 0.89, 95% CI = 0.81-0.98, p = 0.01, N = 6414) were protective against schizophrenia.
|
28864885 |
2018 |
|
rs6994992
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A functional polymorphism (SNP8NRG243177/rs6994992; C/T) in the promoter region of the brain-specific type IV neuregulin-1 gene ( NRG1) has been associated with psychiatric disorders (e.g. schizophrenia and bipolar disorder) that often present higher odds of smoking, alcohol and illicit drug use.
|
27353026 |
2017 |
|
rs3924999
|
|
|
0.090 |
GeneticVariation |
BEFREE |
For NRG1 polymorphisms, in the early onset subgroup (≤25years), the rs3924999 G/G genotype was susceptible to schizophrenia</span>.
|
27236031 |
2016 |
|
rs11989919
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The haplotype rs4512342-rs6982890 showed association with schizophrenia (P = 0.03 for haplotype "TC" after correction), and haplotype rs4531002-rs11989919 proved to be a shared risk factor for both major depressive disorder ("CC": corrected P = 0.009) and bipolar disorder ("CT": corrected P = 0.003).
|
26888291 |
2016 |
|
rs4236710
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among the sites, rs4236710 (corrected Pgenotye = 0.015) and rs4512342 (Pallele = 0.03, Pgenotye = 0.045 after correction) were associated with schizophrenia, and rs2919375 (corrected Pgenotye = 0.004) was associated with major depressive disorder.
|
26888291 |
2016 |
|
rs4512342
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The haplotype rs4512342-rs6982890 showed association with schizophrenia</span> (P = 0.03 for haplotype "TC" after correction), and haplotype rs4531002-rs11989919 proved to be a shared risk factor for both major depressive disorder ("CC": corrected P = 0.009) and bipolar disorder ("CT": corrected P = 0.003).
|
26888291 |
2016 |
|
rs4531002
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The haplotype rs4512342-rs6982890 showed association with schizophrenia (P = 0.03 for haplotype "TC" after correction), and haplotype rs4531002-rs11989919 proved to be a shared risk factor for both major depressive disorder ("CC": corrected P = 0.009) and bipolar disorder ("CT": corrected P = 0.003).
|
26888291 |
2016 |
|
rs6982890
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The haplotype rs4512342-rs6982890 showed association with schizophrenia (P = 0.03 for haplotype "TC" after correction), and haplotype rs4531002-rs11989919 proved to be a shared risk factor for both major depressive disorder ("CC": corrected P = 0.009) and bipolar disorder ("CT": corrected P = 0.003).
|
26888291 |
2016 |
|
rs17673138
|
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association study identifies common variants associated with pharmacokinetics of psychotropic drugs.
|
25944848 |
2015 |
|
rs6994992
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To determine the genetic association between qualitative and quantitative traits of autism spectrum disorder (ASD) and neuregulin 1 (NRG1)-a schizophrenia candidate gene-we examined six single nucleotide polymorphisms (SNPs) in NRG1 using a family-based association test (FBAT) in Korean families with ASD. rs35753505 and rs6994992 SNPs in NRG1 revealed a statistically significant family-based association with three quantitative traits for sociality.
|
25858800 |
2015 |
|
rs17603876
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Meta-analysis of this population of Indo-European and Dravidian ancestry identified three strongly associated variants with schizophrenia: STT3A (rs548181, p=1.47×10(-5)), NRG1 (rs17603876, p=8.66×10(-5)) and GRM7 (rs3864075, p=4.06×10(-3)).
|
25579050 |
2015 |
|
rs6994992
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Homozygosity for the schizophrenia risk allele (T) of rs6994992 conferred lower cortical NRG1-IVNV levels.
|
24935406 |
2014 |
|
rs6994992
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Schizophrenia-risk variant rs6994992 in the neuregulin-1 gene on brain developmental trajectories in typically developing children.
|
24865593 |
2014 |
|
rs3924999
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Our study established a significant association of rs35753505 with schizophrenia but no association with rs3924999 and rs2954041.
|
25106628 |
2014 |
|
rs10503929
|
|
|
0.030 |
GeneticVariation |
BEFREE |
To further support the utility of this phenotype, we studied its test-retest reliability, its potential brain structural contributions, and the effects of a protective missense variant in neuregulin 1 (NRG1) linked to schizophrenia by meta-analysis (ie, rs10503929).
|
24622944 |
2014 |
|
rs2954041
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Our study established a significant association of rs35753505 with schizophrenia but no association with rs3924999 and rs2954041.
|
25106628 |
2014 |
|
rs6994992
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Three variants and one microsatellite showed allelic association with SZ (rs35753505, rs4733263, rs6994992, and microsatellite 420M9-1395, p≤0.05 uncorrected for multiple comparisons).
|
23360725 |
2013 |
|
rs3924999
|
|
|
0.090 |
GeneticVariation |
BEFREE |
We failed to demonstrate a significant association between rs2954041 and rs3924999 with schizophrenia in the three ethnic groups studied (Malay, Chinese, and Indian), while rs764059 was found to be monomorphic.
|
23489597 |
2013 |
|
rs2954041
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We failed to demonstrate a significant association between rs2954041 and rs3924999 with schizophrenia in the three ethnic groups studied (Malay, Chinese, and Indian), while rs764059 was found to be monomorphic.
|
23489597 |
2013 |
|
rs764059
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We failed to demonstrate a significant association between rs2954041 and rs3924999 with schizophrenia in the three ethnic groups studied (Malay, Chinese, and Indian), while rs764059 was found to be monomorphic.
|
23489597 |
2013 |
|
rs10503899
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Multifaceted genomic risk for brain function in schizophrenia.
|
22440650 |
2012 |
|
rs3924999
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The G/G carriers of rs3924999 tended to perform worse in the P300 latency as compared to A/A or A/G carriers both in the schizophrenia and controls.
|
22467496 |
2012 |
|
rs6994992
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The objective of this cross-sectional genetic association study was to determine the relationship of six core single-nucleotide polymorphisms within the NRG1 gene identified as promising schizophrenia risk genes (rs6994992, SNP8NRG221132, SNP8NRG241930, rs3924999, rs2439272 and rs10503929) to prepulse inhibition (PPI) of the acoustic startle reflex, a well validated schizophrenia endophenotype.
|
21035784 |
2011 |
|
rs3924999
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The objective of this cross-sectional genetic association study was to determine the relationship of six core single-nucleotide polymorphisms within the NRG1 gene identified as promising schizophrenia risk genes (rs6994992, SNP8NRG221132, SNP8NRG241930, rs3924999, rs2439272 and rs10503929) to prepulse inhibition (PPI) of the acoustic startle reflex, a well validated schizophrenia endophenotype.
|
21035784 |
2011 |